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Autoimmune haemolytic anaemia emerging during Campath treatment in a patient …
Campath is being employed for the treatment of autoimmune haemolytic anemia (AIHA) whether or not associated to B cell chronic lymphoid leukaemia (CLL). CD5 negative CLL is relatively uncommon and runs an indolent course. We report a CD5 negative CLL patient who developed AIHA associated with cytomegalovirus infection reactivation whilst on treatment with Campath for progressive disease.
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Impact of erdosteine on chronic bronchitis and COPD: A meta-analysis
A previous meta-analysis suggested that the treatment with erdosteine was associated with significant amelioration of the cumulative global efficacy index and symptoms in comparison to placebo or other mucolytics. However, this conclusion was criticized because the meta-analysis, as it had been done, made it impossible to preclude the potential operation of selection biases within and across t…
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Prevention of taxane-associated acute pain syndrome with etoricoxib for patie…
For patients with breast cancer who receive docetaxel chemotherapy, taxane-associated acute pain syndrome (T-APS), considered a form of neural pathology, is a significant clinical problem. We evaluated the effect of prophylactic etoricoxib on T-APS in patients with breast cancer.
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Alemtuzumab Plus Cyclosporine Treatment of the Autoimmune Hemolytic Anemia in…
An adult male underwent a bowel transplant for tufting enteropathy, receiving alemtuzumab, tacrolimus, and steroids as immunosuppressants. Five years later, he developed an autoimmune hemolytic anemia (AIHA), anti-IgG positive, with reduced reticulocyte count, leukopenia, and thrombocytopenia with antiplatelet antibodies. After an unsuccessful initial treatment with high dose steroids, reductio…
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Fluid Management in Acute Kidney Injury
Correction of intravascular hypovolemia is a key component of the prevention and management of acute kidney injury (AKI), but excessive fluid administration is associated with poor outcomes, including the development and progression of AKI. There is growing evidence that fluid administration should be individualized and take into account patient characteristics, nature of the acute illness and…
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The State of The Laryngoscope 2017.
I am pleased to report on the recent developments in The Laryngoscope—the official journal of the Triological Society and part of the Society’s outstanding publishing franchise. The Laryngoscope has been in publication since July 1896. It is an honor to be associated with this prestigious journal, which has had a historic and ongoing impact on our specialty
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Classics from The Laryngoscope: Celebrating 120 Years of Impact
In this issue, we have reprints from two classic articles, which were published in this journal, both on the field of outcomes research. It gives me great pleasure to write this—outcomes research being my own area of academic interest—and also great pride that these two seminal papers by pioneers in the field were published in The Laryngoscope
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Ganglion Cell Populations in Normal and Pathological Human Cochleae: Implicat…
This classic article meticulously detailed the spiral ganglion cell (SGC) populations in 100 patients with variable degrees of hearing loss and known diagnoses to assess the correlation with speech discrimination scores and to hypothesize upon the inherent ability to stimulate the remaining spiral ganglia successfully with cochlear implants
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Idiopathic Pulmonary Fibrosis.
The family of interstitial lung diseases is characterized by cellular proliferation, interstitial inflammation, fibrosis, or a combination of such findings within the alveolar wall that is not due to infection or cancer.1 Interstitial fibrosis is the predominant phenotype in most cases. The majority of patients with interstitial fibrosis ultimately receive a diagnosis of chronic hypersensitivi…
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Respiratory Failure
Respiratory failure in patients admitted to critical care unit (CCU) is a major cause of morbidity and mortality. Patients can get into CCU because of respiratory failure secondary to pulmonary pathology like pneumonia; in many other patients respiratory failure is secondary to sepsis, cardiac failure or neurological disorders. Obviously, respiratory failure involves diverse pathology
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