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Granulocyte Colony Stimulating Factor Receptor (G-CSFR) signaling in severe c…
Granulocyte colony stimulating factor (G-CSF) is a hematopoietic cytokine that stimulates neutrophil production and hematopoietic stem cell mobilization by initiating the dimerization of homodimeric granulocyte colony stimulating factor receptor (G-CSFR). Different mutations of CSF3R have been linked to a unique spectrum of myeloid disorders and related malignancies. Myeloid disorders caused by…
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Occupational and Environmental Lung Disease
The association of occupational lung disease (OLD) with mining has been recognized since the 1500s when silica exposure and tuberculosis were described by Agricola.1 Occupational and environmental lung diseases still remain major causes of pulmonary impairment worldwide. Globally, Driscoll and colleagues2 report an estimated 386,000 respiratory deaths and almost 6.6 million disability adjusted…
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SGLT-2 inhibitors and GLP-1 receptor agonists for nephroprotection and cardio…
Chronic kidney disease (CKD) in patients with diabetes mellitus (DM) is a major problem of public health. currently, many of these patients experience progression of cardiovascular and renal disease, even when receiving optimal treatment. In previous years, several new drug classes for the treatment of type 2 DM have emerged, including inhibitors of renal sodium–glucose cotransporter-2 (SGLT…
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Pregnancy in women with systemic lupus erythematosus (SLE)
Formany years pregnancy has been contraindicated in patients with SLE, particularlywhen kidney involvement was present. Today, pregnancy is no longer considered impossible in women with lupus. Yet, lupus pregnancies are still considered high-risk. The prognosis has considerably improved for pregnant women but the fetal risk, although progressively reduced, is still higher in pregnancies of pati…
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Diagnosis of Hepatic Nodules in Patients at Risk for Q1 Hepatocellular Carcin…
Unequivocal diagnosis with avoidance of falsepositive results is very relevant in patients with liver disease in whom an imaging technique detects a nodule that raises the potential emergence of hepatocellular carcinoma (HCC). Although biopsy confirmation is standard in most cancers, several studies have shown that reliable HCC diagnosis may be established by imaging techniques in patients wit…
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Pola Penggunaan Antibiotik Profilaksis pada Pasien Bedah Caesar (Sectio Caesa…
Telah dilakukan penelitian pola penggunaan antibiotik profilaksis pada pasien bedah caesar (Seksio Sesare) di Rumah Sakit Pekanbaru Medical Center (PMC) tahun 2014. Tujuan penelitian ini untuk mengetahui pola penggunaan antibiotik profilaksis bedah sesar. Jenis penelitian yang dilakukan adalah penelitian observasional yang dirancang dengan studi deskriptif dengan cara melakukan kajian terhadap …
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Hypertension, left ventricular hypertrophy, and sudden cardiac death
Hypertension (HTN) is among the most common, noncommunicable disease in the world. Approximately 80 million people (32.6%) in the United States [1] and one billion worldwide suffer from HTN [2], and the prevalence may be even higher as the diagnosis is based on an objective test (i.e., blood pressure measurement). Longterm HTN leads to hypertensive heart disease, and is the result of anatomical…
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EVALUASI PENGGUNAAN ANTIBIOTIK PROFILAKSIS TERHADAP KEJADIAN INFEKSI LUKA OPE…
Infeksi nosokomial merupakan penyebab utama tingginya angka kesakitan dan kematian di dunia. Pada tahun 2002 CDC memperkirakan angka kejadian infeksi nosokomial di rumah sakit 1,7 juta orang dan sekitar 99.000 orang meninggal karena infeksi ini.Infeksi luka operasi (ILO) merupakan salah satu dari infeksi nosokomial mayoritas yang terjadi di rumah sakit. Penggunaan antibiotik profilaksis yang se…
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Insulin treatment in children and adolescents with diabetes
Insulin treatment must be started as soon as possible after diagnosis (usually within 6h if ketonuria is present) to prevent metabolic decompensation and diabetic ketoacidosis (A).
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What Have We Learned From the Typhoid Fever Surveillance in Africa Program?
The Typhoid Fever Surveillance in Africa Program (TSAP) was established in 2009 to fill the data void concerning invasive Salmonella disease in sub-Saharan Africa, and to specifically estimate the burden of bloodstream infections caused by the key pathogen, Salmonella enterica serovar Typhi. TSAP has achieved this ambitious target, finding high incidences of typhoid fever in both rural and u…
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