Sensory Integration Therapies for Children With Developmental and Behavioral …

Sensory-based therapies are increasingly used by occupational therapists and sometimes by other types of therapists in treatment of children with developmental and behavioral disorders. Sensory-based therapies involve activities that are believed to organize the sensory system by providing vestibular, proprioceptive, auditory, and tactile inputs. Brushes, swings, balls, and other specially desi…

Sensory-Processing Disorder in Children With Cochlear Implants

We examined sensory-processing disorder (SPD) in children with cochlear implants and explored the relationship between SPD and duration of hearing loss or duration of cochlear implant use. Caregivers of 30 children completed the Sensory Profile Questionnaire (SPQ). Seventy percent of the children showed “at-risk” or “different” behaviors in one or more of five categories of the SPQ: …

New agents to reduce cholesterol levels: implications for nephrologists

Statins and ezetimibe effectively reduce the burden of cardiovascular (CV) disease in patients with chronic kidney disease (CKD). Unfortunately, many subjects still die or have CV events despite cholesterol-lowering therapy. This is particularly true in patients with more advanced CKD. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that induces the degradation of the…

Citicoline for Acute Ischemic Stroke: A Systematic Review and Formal Meta-ana…

Citicoline is a drug approved for the treatment of acute ischemic stroke. Although evidence of its efficacy has been reported, recently published results of a large placebo-controlled clinical trial did not show differences. This study aims to assess whether starting citicoline treatment within 14 days after stroke onset improves the outcome in patients with acute ischemic stroke, as compared …

Citicoline: pharmacological and clinical review, 2016 update

This review is based on the previous one published in 2010 –Secades JJ. Citicoline: pharmacological and clinical review, 2010 update. Rev Neurol 2011; 52 (Suppl 2): S1-62–, incorporating 183 new references, having all the information available to facilitate the access to the information in one document. This review is focused on the main indications of the drug, as acute stroke and its s…

Necrotizing fasciitis: Classification, diagnosis, and management

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Sepsis and septic shock

Sepsis is a common condition that is associated with unacceptably high mortality and, for many of those who survive,rnlong-term morbidity. Increased awareness of the condition resulting from ongoing campaigns and the evidence arisingrnfrom research in the past 10 years have increased understanding of this problem among clinicians and lay people, andrnhave led to improved outcomes. The World Hea…

Competing risks model in screening for preeclampsia by maternal characteristi…

To develop a model for preeclampsia (PE) based on maternal demographic characteristics and medical history

Genetic and non-genetic risk factors for pre-eclampsia: umbrella review of sy…

To summarize evidence from the literature on genetic and non-genetic risk factors associated with pre-eclampsia (PE), assess the presence of statistical bias in the studies and identify risk factors for which there is robust evidence supporting their association with PE.

TLR2 agonism reverses chemotherapy-induced neutropenia in Macaca fascicularis

Neutropenia is a common consequence of radiation and chemotherapy in cancer patients. The resulting immunocompromised patients become highly susceptible to potentially life-threatening infections. Granulocyte colony-stimulating factor (G-CSF) is known to stimulate neutrophil production and is widely used as a treatment of chemotherapy-induced neutropenia. A small-molecule G-CSF secretagogue wi…