IMPROVING GENERAL PRACTICE: A CALL TO ACTION – PHASE ONE REPORT

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PubMed Labs: an experimental system for improving biomedical literature search

PubMed is a freely accessible system for searching the biomedical literature, with ∼2.5 million users worldwide on an average workday. In order to better meet our users’ needs in an era of information overload, we have recently developed PubMed Labs (www.pubmed.gov/labs), an experimental system for users to test new search features/tools (e.g. Best Match) and provide feedback, which enables…

Inhibition of oxidative phosphorylation suppresses the development of osimert…

Metabolic plasticity is an emerging hallmark of cancer, and increased glycolysis is often observed in transformed cells. Small molecule inhibitors that target driver oncogenes can potentially inhibit the glycolytic pathway. Osimertinib (AZD9291) is a novel EGFR tyrosine kinase inhibitor (TKI) that is potent and selective for sensitising (EGFRm) and T790M resistance mutations.

EGFR T790M detection and osimertinib treatment response evaluation by liquid …

Lung adenocarcinoma with EGFR activating mutations will inevitably acquire resistance to first generation TKIs. Acquired EGFR T790M mutation causes about 50% of these resistance cases. Droplet digital PCR ddPCR) and cobas enables quantification of T790M mutation. Whether these methods can predict clinical response of osimertinib treatment is unknown.

EGFR-mutant Non-small Cell Lung Cancer Accompanied by Transient Asymptomatic …

A 69-year-old man with post-operative recurrence of lung adenocarcinoma was treated with multiple chemotherapies, including epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors. A second biopsy revealed an EGFR T790M mutation. As 10th-line chemotherapy, osimertinib was initiated. After 24 weeks, chest computed tomography (CT) revealed asymptomatic ground-glass opacities in both lo…

Type 2 diabetes mellitus in children and adolescents

Type 2 diabetes mellitus is emerging as a new clinical problem within pediatric practice. Recent reports indicate an increasing prevalence of type 2 diabetes mellitus in children and adolescents around the world in all ethnicities, even if the prevalence of obesity is not increasing any more.

Discovering biomedical semantic relations in PubMed queries for information r…

Identifying relevant papers from the literature is a common task in biocuration. Most current biomedical literature search systems primarily rely on matching user keywords. Semantic search, on the other hand, seeks to improve search accuracy by understanding the entities and contextual relations in user keywords

Diagnosis and Classification of Diabetes Mellitus

Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels

Personalized medicine in diabetes mellitus: current opportunities and future …

Diabetes mellitus affects approximately 382 million individuals worldwide and is a leading cause of morbidity and mortality. Over 40 and nearly 80 genetic loci influencing susceptibility to type 1 and type 2 diabetes, respectively, have been identified. Additionally, there is emerging evidence that some genetic variants help to predict response to treatment. Other variants confer apparent prote…

Interactive Web-based regional journal club for postgraduate year 2 pharmacy …

Participation in journal club presentations has been repeatedly demonstrated to develop therapeutic knowledge, increase awareness of current research, and enhance critical thinking skills.1,2 However, literature evaluation activities may prove challenging for student pharmacists and residents. For pharmacy preceptors, initiating and maintaining a regular and effective journal club can be diffic…