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The changing role of TGFβ in healthy, ageing and osteoarthritic joints
Transforming growth factor‑β (TGFβ) is a pleiotropic cytokine that is important in the regulation of joint homeostasis and disease. TGFβ signalling is induced by loading and has an important function in maintaining the differentiated phenotype of articular chondrocytes
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The role of metabolism in the pathogenesis of osteoarthritis
Metabolism is important for cartilage and synovial joint function. Under adverse microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a resting regulatory state to a highly metabolically activate state to maintain energy homeostasis. This phenomenon also leads to an increase in metabolic intermediates for the biosynthesis of inflammatory and degradative prote…
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Osteoarthritis
Osteoarthritis (OA) is the most common joint disorder, is associated with an increasing socioeconomic impact owing to the ageing population and mainly affects the diarthrodial joints. Primary OA results from a combination of risk factors, with increasing age and obesity being the most prominent. The concept of the pathophysiology is still evolving, from being viewed as cartilage-limited to a m…
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Treatment of severe autoimmune hemolytic anemia in B-cell chronic lymphocytic…
We read with interest the article by Karlsson et al.1 in Leukemia (2007), which reports five patients treated successfully with alemtuzumab (anti-CD52) for refractory autoimmune hemolytic anemia (AIHA) complicating B-cell chronic lymphocytic leukemia (B-CLL).
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Simultaneous early-onset severe autoimmune hemolytic anemia and albuminuria d…
Alemtuzumab, approved for multiple sclerosis (MS), can cause secondary autoimmune adverse events including thyroid disorders, immune thrombocytopenia (ITP), and glomerular nephropathies. Non-ITP autoimmune cytopenias are rarely reported.
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Life-threatening autoimmune warm hemolytic anemia following treatment for mul…
Alemtuzumab is a humanized monoclonal antibody directed at CD52 approved as a disease- modifying therapy for relapsing forms of multiple sclerosis (MS).
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Recent advances in the management of radiation colitis
Radiation colitis, an insidious, progressive disease of increasing frequency, develops 6 mo to 5 years after regional radiotherapy for malignancy, owing to the deleterious effects of the latter on the colon and the small intestine. When dealing with radiation colitis and its complications, the most conservative modality should be employed because the areas of intestinal injury do not tend to h…
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Prevalence of Pneumoconiosis in Hubei, China from 2008 to 2013
We have investigated newly reported pneumoconiosis cases in the province of Hubei, China from 2008 to 2013, to identify the major problems and challenges, and explore possible solutions for its prevention and control. We analyzed the data on new cases of pneumoconiosis from annual reports, including case distributions, patient ages, exposure duration, disease stages, and enterprise types
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Acute symptomatic seizures in CNS infection
To determine the frequency and aetiology of acute symptomatic seizures in central nervous system (CNS) infections and to assess the clinical factors predicting the occurrence of the seizures, we retrospectively reviewed the medical records of patients diagnosed with CNS infections from 2000 to 2005. One hundred and forty-seven atients were included in the study.
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Recovery of consciousness following acute symptomatic seizures due to central…
The aim of this study was to assess whether acute symptomatic epileptic seizures associated with central nervous system infections (ASinf) have a different ictal and postictal course to seizures of other aetiologies
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