Current state of the art for renal replacement therapy in critically ill pati…

Acute kidney injury (AKI) is associated with incremental risk for death and chronic kidney disease and represents a mounting clinical challenge for healthcare professionals. Renal replacement therapy (RRT) use in ICU settings is rising, likely in response to similar trends in AKI, taken together with an ageing population burdened by high prevalence of multi-morbidity and high illness acuity

Targeted Deletion of the Sclerostin Gene in Mice Results in Increase Bone For…

Sclerosteosis is a rare high bone mass genetic disorder in humans caused by inactivating mutations in SOST, the gene encoding sclerostin. Based on these data, sclerostin has emerged as a key negative regulator of bone mass. We generated SOST knockout (KO) mice to gain a more detailed understanding of the effects of sclerostin deficiency on bone

The influence of different fever definitions on diagnostics and treatment aft…

There is no evidence-based definition of the temperature limit defining fever (TLDF) in children with neutropenia. Lowering the TLDF is known to increase the number of episodes of fever in neutropenia (FN). This study aimed to investigate the influence of a lower versus standard TLDF on diagnostics and therapy

Subclinical Hypothyroidism

A 71-year-old woman reports fatigue and mild depression. She has hypertension and had a myocardial infarction 4 years ago. She has a family history of autoimmune thyroid disease. The physical examination is unremarkable. No thyroid enlargement is present. Laboratory results include normal levels of hemoglobin, creatinine, and calcium and a normal erythrocyte sedimentation rate. The thyrotro…

The roles of melatonin and light in the pathophysiology and treatment of circ…

Normal circadian rhythms are synchronized to a regular 24 h environmental light–dark cycle, and the suprachiasmatic nucleus and the hormone melatonin have important roles in this process. Desynchronization of circadian rhythms, as occurs in chronobiological disorders, can produce severe disturbances in sleep patterns

Treatment of a Case of Advanced Sleep Phase SYndrome by Phase Advance Chronot…

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Efficacy of Oral Clonidine Premedication in Children

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Clinical Significance of Mitral Regurgitation After Acute Myocardial Infarction

Mitral regurgitation (MR) may complicate acute myocardial infarction (MI). However, it is not known whether mild MR is an independent predictor of post-MI outcome

Antibiotic prescribing for the future: exploring the attitudes of trainees in…

Antibiotic resistance is a public health concern worldwide. A high proportion of antibiotics are prescribed in primary care, often for conditions where there is no evidence of benefit. Without a change in these prescribing patterns, resistance will persist as a significant problem in the future. Little is known about how trainees in general practice perceive and develop their prescribing.

Clinical drug trials in general practice: a 10-year overview of protocols

Drugs predominantly prescribed in general practice should ideally be tested in that setting; however, little is known about drug trials in general practice. Our aim was to describe drug trials in Norwegian general practice over the period of a decade.