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New therapeutic strategies in systemic lupus erythematosus management
The current treatment approach for systemic lupus erythematosus (SLE), as outlined in the recommendations by international medical associations including EUL AR and the ACR , is mostly eminence- based rather than evidence- based. However, knowledge on SLE is growing quickly , and such new advances need to be translated into clinical practice. Questions remain regarding the choice and timing of…
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A comprehensive review on clinical outcome of probiotic and synbiotic therapy…
The composition of gut microflora and its metabolic activity are closely correlated with the host immune system, and the changes in the biometric of the microbiome lead to inflammatory diseases like inflammatory bowel disease. The supplementation of probiotics and synbiotic could indeed manipulate the microflora, which can be an alternative therapy for ulcerative colitis, and Crohn’s disease.
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Screening for hemosiderosis in patients receiving multiple red blood-cells tr…
The dramatic impact of hemosiderosis on survival in chronically transfused patients with hereditary anaemia is well known. We evaluated whether patients receiving multiple red blood-cell (RBC) transfusions are adequately screened for hemosiderosis
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Extracorporeal Membrane Oxygenation for Adult Respiratory Failure : 2017 Update
The use of extracorporeal membrane oxygenation (ECMO) for respiratory failure in adults is growing rapidly, driven in large part by advances in technology, which have made ECMO devices easier to implement and safer and more efficient. Accompanying this increase in use is a nearly exponential increase in ECMO-related literature. However, the great majority of the literature is composed of retro…
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Heparin induced thrombocytopenia: diagnosis and management update
Heparin-induced thrombocytopenia (HIT) is a potentially devastating immune mediated adverse drug reaction caused by the emergence of antibodies that activate platelets in the presence of heparin. Despite thrombocytopenia, bleeding is rare; rather, HIT is strongly associated with thromboembolic complications involving both the arterial and venous systems. A number of laboratory tests are avai…
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Heparin-induced thrombocytopenia (HIT): Identification and treatment pathways
Heparin is a proven effective anticoagulant therapy in many thrombotic conditions such as acute coronary syndrome and deep venous thrombosis, where heparin therapy is recommended after administration of thrombolytic agent to reduce mortality. Combining heparin with Aspirin reduces the risk of thrombosis by 75%2. Although heparin is highly successful in reducing morbidity and mortality associat…
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Heparin-Induced Thrombocytopenia
Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic antibodies to PF4/heparin bind and activate cellular FcγRIIA on platelets and monocytes to propagate a hypercoagulable state culminating in life-threatening thrombosis. It is now recognized that anti- PF4/heparin antibodies de…
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A Questionnaire to Measure Quality of Life in Adults with Nocturnal Allergic …
The aim of this study was to develop the Nocturnal Rhinoconjunctivitis Quality of Life Questionnaire (NRQLQ) to measure the functional problems that are most troublesome to patients with nocturnal allergic rhinoconjunctivitis (NAR).
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Incidence Trends of Esophageal and Gastric Cancer Subtypes
There is limited information on contemporary incidence rates and trends, by race, ethnicity, and age, for major subtypes of esophageal and gastric cancer in the United States. We examined the most recent nationwide incidence data for esophageal squamous cell carcinoma, esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA), and gastric non-cardia adenocarcinoma (GNCA) by race, et…
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Maintenance Treatment of Eosinophilic Esophagitis with Swallowed Topical Ster…
Although swallowed topical corticosteroids (STCs) are effective in inducing remission of active eosinophilic esophagitis (EoE), there are few data on maintenance of long-term remission. We evaluated the long-term effectiveness of STC therapy for adults with EoE.
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