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Fluid Management in Acute Kidney Injury
Correction of intravascular hypovolemia is a key component of the prevention and management of acute kidney injury (AKI), but excessive fluid administration is associated with poor outcomes, including the development and progression of AKI. There is growing evidence that fluid administration should be individualized and take into account patient characteristics, nature of the acute illness and…
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The State of The Laryngoscope 2017.
I am pleased to report on the recent developments in The Laryngoscope—the official journal of the Triological Society and part of the Society’s outstanding publishing franchise. The Laryngoscope has been in publication since July 1896. It is an honor to be associated with this prestigious journal, which has had a historic and ongoing impact on our specialty
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Classics from The Laryngoscope: Celebrating 120 Years of Impact
In this issue, we have reprints from two classic articles, which were published in this journal, both on the field of outcomes research. It gives me great pleasure to write this—outcomes research being my own area of academic interest—and also great pride that these two seminal papers by pioneers in the field were published in The Laryngoscope
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Ganglion Cell Populations in Normal and Pathological Human Cochleae: Implicat…
This classic article meticulously detailed the spiral ganglion cell (SGC) populations in 100 patients with variable degrees of hearing loss and known diagnoses to assess the correlation with speech discrimination scores and to hypothesize upon the inherent ability to stimulate the remaining spiral ganglia successfully with cochlear implants
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Idiopathic Pulmonary Fibrosis.
The family of interstitial lung diseases is characterized by cellular proliferation, interstitial inflammation, fibrosis, or a combination of such findings within the alveolar wall that is not due to infection or cancer.1 Interstitial fibrosis is the predominant phenotype in most cases. The majority of patients with interstitial fibrosis ultimately receive a diagnosis of chronic hypersensitivi…
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Respiratory Failure
Respiratory failure in patients admitted to critical care unit (CCU) is a major cause of morbidity and mortality. Patients can get into CCU because of respiratory failure secondary to pulmonary pathology like pneumonia; in many other patients respiratory failure is secondary to sepsis, cardiac failure or neurological disorders. Obviously, respiratory failure involves diverse pathology
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Approach to respiratory failure in emergency department
The goal of this review is to provide update recommendations that can be used by emergency physicians who provide primary cares to patients with Acute Respiratory Failure (ARF), from the admission to an emergency department through the first 24 to 48 hours of hospitalization. This work wants to address the diagnosis and emergency medical care of ARF and the management of medical complications
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New insights into the immunopathogenesis of systemic lupus erythematosus
The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes contributions from the environment, stochastic factors, and genetic susceptibility. Great gains have been made in understanding SLE through the use of genetic variant identification, mouse models, gene expression studies, and epigenetic analyses. Collectively, these studies support the concept that defective cl…
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Lupus in crisis: as failures pile up, clinicians call for new tools
It was another bad year for drug development in lupus. The biggest setback for the field came in late August when AstraZeneca announced that its blockbuster hope anifrolumab, an antibody directed at a subunit of the type I interferon receptor, flunked the first of its two pivotal trials. Then came more bad news when UCB and Biogen reported toward the end of October that their phase 2b study of …
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Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70% of patients with SLE will develop lupus nephritis. Renal assault during SLE is initiated by genes that breach immune tolerance and promote autoantibody production. These genes might act in concert with other genetic…
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