The roles of melatonin and light in the pathophysiology and treatment of circ…

Normal circadian rhythms are synchronized to a regular 24 h environmental light–dark cycle, and the suprachiasmatic nucleus and the hormone melatonin have important roles in this process. Desynchronization of circadian rhythms, as occurs in chronobiological disorders, can produce severe disturbances in sleep patterns

Treatment of a Case of Advanced Sleep Phase SYndrome by Phase Advance Chronot…

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Efficacy of Oral Clonidine Premedication in Children

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Clinical Significance of Mitral Regurgitation After Acute Myocardial Infarction

Mitral regurgitation (MR) may complicate acute myocardial infarction (MI). However, it is not known whether mild MR is an independent predictor of post-MI outcome

Antibiotic prescribing for the future: exploring the attitudes of trainees in…

Antibiotic resistance is a public health concern worldwide. A high proportion of antibiotics are prescribed in primary care, often for conditions where there is no evidence of benefit. Without a change in these prescribing patterns, resistance will persist as a significant problem in the future. Little is known about how trainees in general practice perceive and develop their prescribing.

Clinical drug trials in general practice: a 10-year overview of protocols

Drugs predominantly prescribed in general practice should ideally be tested in that setting; however, little is known about drug trials in general practice. Our aim was to describe drug trials in Norwegian general practice over the period of a decade.

IMPROVING GENERAL PRACTICE: A CALL TO ACTION – PHASE ONE REPORT

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PubMed Labs: an experimental system for improving biomedical literature search

PubMed is a freely accessible system for searching the biomedical literature, with ∼2.5 million users worldwide on an average workday. In order to better meet our users’ needs in an era of information overload, we have recently developed PubMed Labs (www.pubmed.gov/labs), an experimental system for users to test new search features/tools (e.g. Best Match) and provide feedback, which enables…

Inhibition of oxidative phosphorylation suppresses the development of osimert…

Metabolic plasticity is an emerging hallmark of cancer, and increased glycolysis is often observed in transformed cells. Small molecule inhibitors that target driver oncogenes can potentially inhibit the glycolytic pathway. Osimertinib (AZD9291) is a novel EGFR tyrosine kinase inhibitor (TKI) that is potent and selective for sensitising (EGFRm) and T790M resistance mutations.

EGFR T790M detection and osimertinib treatment response evaluation by liquid …

Lung adenocarcinoma with EGFR activating mutations will inevitably acquire resistance to first generation TKIs. Acquired EGFR T790M mutation causes about 50% of these resistance cases. Droplet digital PCR ddPCR) and cobas enables quantification of T790M mutation. Whether these methods can predict clinical response of osimertinib treatment is unknown.