Cardiovascular Death and Left Ventricular Remodeling Two Years After Myocardi…

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Better with Ultrasound: Subclavian Central Venous Catheter Insertion

The Q2 insertion of a subclavian central venous catheter is generally associated with a high rate of success and a favorable risk profile. The use of ultrasound for procedural guidance has been demonstrated to further increase the rate of success and reduce the risk of specific mechanical complications, especially in patients with difficult surface anatomy

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

The cardiovascular safety profile of dapagliflozin, a selective inhibitor of sodium– glucose cotransporter 2 that promotes glucosuria in patients with type 2 diabetes, is undefined.

Community-Acquired Thoracic Empyema in Young Adults

To evaluate the clinical characteristics, bacteriology, and therapeutic outcomes of community-acquired thoracic empyema (CATE) in young adults.

Quantification of Complications of Tunneled Hemodialysis Catheters

Tunneled central venous catheters (CVCs) are widely regarded as a suboptimal form of vascular access for hemodialysis (HD), when compared with arteriovenous fistulas (AVFs) or grafts (AVGs).

2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Manag…

Since 1980, the American College of Cardiology (ACC) and American Heart Association (AHA) have translated scientific evidence into clinical practice guidelines (guidelines) with recommendations to improve cardiovascular health. These guidelines, which are based on systematic methods to evaluate and classify evidence, provide a cornerstone for quality cardiovascular care.

Current state of the art for renal replacement therapy in critically ill pati…

Acute kidney injury (AKI) is associated with incremental risk for death and chronic kidney disease and represents a mounting clinical challenge for healthcare professionals. Renal replacement therapy (RRT) use in ICU settings is rising, likely in response to similar trends in AKI, taken together with an ageing population burdened by high prevalence of multi-morbidity and high illness acuity

Targeted Deletion of the Sclerostin Gene in Mice Results in Increase Bone For…

Sclerosteosis is a rare high bone mass genetic disorder in humans caused by inactivating mutations in SOST, the gene encoding sclerostin. Based on these data, sclerostin has emerged as a key negative regulator of bone mass. We generated SOST knockout (KO) mice to gain a more detailed understanding of the effects of sclerostin deficiency on bone

The influence of different fever definitions on diagnostics and treatment aft…

There is no evidence-based definition of the temperature limit defining fever (TLDF) in children with neutropenia. Lowering the TLDF is known to increase the number of episodes of fever in neutropenia (FN). This study aimed to investigate the influence of a lower versus standard TLDF on diagnostics and therapy

Subclinical Hypothyroidism

A 71-year-old woman reports fatigue and mild depression. She has hypertension and had a myocardial infarction 4 years ago. She has a family history of autoimmune thyroid disease. The physical examination is unremarkable. No thyroid enlargement is present. Laboratory results include normal levels of hemoglobin, creatinine, and calcium and a normal erythrocyte sedimentation rate. The thyrotro…