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Konsensus penatalaksanaan hipertensi: update konsensus PERHI 2019
Hipertensi merupakan masalah kesehatan global berakibat peningkatan angka kesakitan dan kematian serta beban biaya kesehatan termasuk di Indonesia. Hipertensi merupakan faktor risiko terhadap kerusakan organ penting seperti otak, jantung, ginjal, retina, pembuluh darah besar (aorta) dan pembuluh darah perifer. Riset Kesehatan Dasar (Riskesdas) tahun 2018 menunjukkan peningkatan prevalensi hip…
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Knowledge Sharing Session : Cara Pintar "Berdamai" dengan Rasa Lapar untuk Tu…
Menurunkan berat badan bukan berarti harus terus menahan lapar. Dexan, mari pelajari cara memahami sinyal tubuh, memilih pola makan yang tepat, dan mengelola rasa lapar secara sehat agar proses penurunan berat badan terasa lebih nyaman, berkelanjutan, dan sesuai dengan aktivitas kerja sehari-hari.
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Immune Persistence Following a Single Dose of Varicella Vaccine: 5-Year and 8…
In recent years, breakthrough varicella cases among individuals who have received a single dose of varicella vaccine (VarV) have increased notably, suggesting that the long-term protection following a one-dose VarV regimen requires further investigation. This study aims to evaluate the immune persistence following a single dose of Sinovac VarV at 5 and 8 years post-vaccination
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Immunogenicity and Safety of a Live Attenuated Varicella Vaccine in Healthy C…
The varicella vaccine (VarV) produced by Sinovac (Dalian) obtained World Health Organization (WHO) prequalification in November 2022. However, no direct comparative studies have been conducted between VarV and other WHO-prequalified varicella vaccines. The study aimed to assess the immunogenicity and safety of Sinovac’s VarV compared with Merck Sharp & Dohme’s (MSD) VARIVAX® (Moorgate, Lo…
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Knowledge Sharing Session: Gatal? Jangan Sembarang Digaruk?
Sebagian Besar Orang Fokus Menghilangkan Gatal dengan Menggaruk. Padahal Mereka Salah Target! Menggaruk atau konsumsi obat sembarangan mungkin meredakan gejala sementara, tetapi tidak menyelesaikan akar masalah. Penyebab gatal bisa sangat beragam dan masing-masing membutuhkan terapi yang berbeda. Kalau penyebabnya salah dikenali, obatnya pun bisa salah. Bukannya sembuh bisa-bisa menjadi semaki…
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A prospective, randomised, investigator-blind, controlled, clinical study on …
The aim of this multicentre, prospective, randomised, investigator blind, controlled clinical trial was to evaluate the clinical efficacy and tolerability of a highly purified human menopausal gonadotrophin (hMG) preparation (Merional-HG) when administered to patients undergoing controlled ovarian stimulation (COS) for in-vitro fertilisation (IVF) procedure enrolled in hospital departments
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Evaluation of the oligosaccharide composition of commercial follicle stimulat…
Glycosylation is an important PTM in proteins, and it is of paramount importance for the manufacture and efficacy of therapeutic glycoproteins. The elucidation of the glycosylation patterns is greatly hampered by the structural heterogeneity, which involves the oligosaccharide moieties, and sometimes also the protein chain. Several strategies are used to map the glycosylation state of glycoprot…
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Comparative effectiveness of inhaled fluticasone propionate/salmeterol and bu…
Asthma affects over 260 million people globally, with significant health impacts. The Global Initiative for Asthma (GINA) 2024 report recommends inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) combinations, including fluticasone propionate/salmeterol (FP/SAL) and budesonide/formoterol (BUD/FOR), for maintenance treatment. Both combinations have demonstrated clinical benefits, with pre…
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Dexmedetomidine vs other sedatives in critically ill mechanically ventilated …
Conventional gabaminergic sedatives such as benzodiazepines and propofol are commonly used in mechanically ventilated patients in the intensive care unit (ICU). Dexmedetomidine is an alternative sedative that may achieve lighter sedation, reduce delirium, and provide analgesia. Our objective was to perform a comprehensive systematic review summarizing the large body of evidence, determining if …
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Dexmedetomidine for treatment of hyperactive delirium in non‑intubated ICU …
In a multicenter, double-blind, placebo-controlled, two-arm, investigator-initiated, randomized trial conducted in 9 ICUs, we randomly assigned non-intubated critically ill adults with hyperactive delirium to receive continuous intravenous infusion of dexmedetomidine or placebo for at least 36 h. The primary outcome was a joint modelling of multiple outcomes of agitation duration (score of + 1 …
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