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Found 15 from your keywords: author=Tjandrawinata RR
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Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lum…
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Trisina JTjandrawinata RR

DLBS1033 is a bioactive protein fraction isolated from Lumbricus rubellus that tends to be unstable when exposed to the gastrointestinal environment. Accordingly, appropriate pharmaceutical development is needed to maximize absorption of the protein fraction in the gastrointestinal tract. In vitro, ex vivo, and in vivo stability assays were performed to study the stability of the bioactive pro…

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Bioequivalence study of two formulations of candesartan cilexetil tablet in h…
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Tjandrawinata RR

This study was a randomized, single- blind, two-period, cross-over study which included 24 healthy adult male and female subjects under fasting conditions. The pharmacokinetic parameters were determined based on the concentrations of candesartan (CAS 139481-59-7), using ultra-pressure high-performance liquid chromatography with a tandem mass spectrometer detector. In each of the two study perio…

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Changes in Immunological Parameters by Standardized Phyllanthus niruri Extrac…
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Tjandrawinata RR

One of traditional herbs used as medicine in many countries for various uses is the herb Phyllanthus niruri L. Many pre-clinical studies have explored its activities on the immune system. Further pre-clinical studies were done to determine its safety and immunomodulating characteristics on mice and rats. The results of these studies suggested that Phyllanthus niruri L extract is able to modulat…

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Gastroprotective Effect of DLBS2411 Bioactive Fraction from Cinnamomum burman…
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Tjandrawinata RR

The study was carried out to evaluate the anti-ulcerative and gastroprotective effect of DLBS2411, a bioactive fraction from Cinnamomum burmannii (Nees & T. Nees) Blume, in Wistar rats (Rattus norvegicus)

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Hydrogen potassium adenosine triphosphatase activity inhibition and downregul…
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Tjandrawinata RR

This study assessed the gastric acid antisecretory effect of DLBS2411 fractionated from Cinnamomum burmannii. Hydrogen potassium adenosine triphosphatase (H+/K+ ATPase) activity and its gene expression were observed, and the antioxidant activity of DLBS2411 was also investigated. Treatment of DLBS2411 decreased the level of H+/K+ ATPase messenger RNA expression on human embryonic kidney 293 cel…

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