Studi fraksi bioaktif telah muncul sebagai bidang transformatif dalam farmakologi modern, menekankan pemurnian dan isolasi senyawa yang dipandu bioassay dengan potensi terapeutik.1,2,3 Makalah ini mengeksplorasi mekanisme, metodologi, dan implikasi fraksi bioaktif dalam memajukan penemuan obat. Mengambil pengetahuan etnofarmakologi, makalah ini menyoroti integrasi k…
DLBS1442, a proprietary and standardized semipolar bioactive extract of the fruit Phaleria macrocarpa, is preclinically proven to have anti-inflammatory properties. The current clinical study evaluated the efficacy and safety of DLBS1442 in alleviating symptoms of premenstrual syndrome and primary dysmenorrhea
DLBS3233 is a standardized extract combination of two Indonesian herbals (Lagerstroemia speciosa L. and Cinnamomum burmanii L.) developed by a patented extraction-technology. DLBS3233 has been proven pre-clinically to have a glucose lowering activity. This Phase 1 clinical study evaluated the safety of DLBS3233 in comparison with the negative-control and pioglitazone 30 mg (active control) in h…
This study aimed to demonstrate the bioequivalence of the Dapagliflozin 10 mg film-coated tablets manufactured by PT Dexa Medica, Indonesia, in comparison with the reference formulation, Forxiga® 10 mg filmcoated tablets, manufactured by AstraZeneca Pharmaceuticals
DLBS1442, a proprietary and standardized semipolar bioactive extract of the fruit Phaleria macrocarpa, is preclinically proven to have anti-inflmmatory properties. The current clinical study evaluated the effiacy and safety of DLBS1442 in alleviating symptoms of premenstrual syndrome and primary dysmenorrhea
The demand of fast-melting tablets has been growing during the last decade. This dosage form is placed in the mouth, allowed to disperse or dissolve in the saliva, and then swallowed. In addition, it can be administered anywhere, without the need for water or chewing. Due its features, the fast-melting tablets will increase patient compliance, especially those who need rapid relief, such as vom…
This study was aimed to evaluate the safety and tolerability of Lumbrokinase DLBS1033 in healthy adult subjects
The geometric mean ratios (90% confidence interval) of the test drug/reference drug for gabapentin were 103.15% (90.38%–117.72%) for AUCt , 103.53% (90.78%–118.07%) for AUCinf, and 108.06% (96.32%–121.24%) for Cmax. The differences in tmax and t1/2 values between the test and reference drug products for gabapentin were not statistically significant. Light-headedness, nausea, and headache …
The present study was conducted to evaluate whether the bioavailability of pregabalin capsules 150 mg manufactured by PT Dexa Medica was equivalent to the reference formulation.
DLBS3233 is a standardized extract combination of two Indonesian herbals (Lagerstroemia speciosa L. and Cinnamomum burmanii L.) developed by a patented extraction-technology. DLBS3233 has been proven pre-clinically to have a glucose lowering activity. This Phase 1 clinical study evaluated the safety of DLBS3233 in comparison with the negative-control and pioglitazone 30 mg (active control) in h…