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Safety of Adding Salmeterol to Fluticasone Propionate in Children with Asthma
Long-acting beta-agonists (LABAs) have been shown to increase the risk of asthmarelated death among adults and the risk of asthma-related hospitalization among children. It is unknown whether the concomitant use of inhaled glucocorticoids with LABAs mitigates those risks. This trial prospectively evaluated the safety of the LABA salmeterol, added to fluticasone propionate, in a fixed-dose combi…
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Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone
The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate
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