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Ketoprofen Pharmacokinetics, Efficacy, and Tolerability in Pediatric Patients
The NSAID ketoprofen is used widely in the management of inflammatory and musculoskeletal conditions, pain, and fever in children and adults. Pharmacokinetic studies show that drug exposure after a single intravenous dose is similar in children and adults (after dose normalization), and thus similar mg /kg bodyweight dosing may be used in children and adults. Ketoprofen crosses the blood-bra…
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Levobupivacaine for Pediatric Spinal Anesthesia
In this clinical trial we evaluated the clinical effects of levobupivacaine in spinal anesthesia in children. An open, noncomparative study was performed on 40 children, aged 1–14 yr, undergoing elective lower abdominal or lower limb surgery. A plain solution of S()- bupivacaine 5 mg/mL at a mean dose of 0.3 mg/kg body weight (range, 0.2– 0.5 mg/kg body weight) was administered via the L3…
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