PRODUCT LITERATURE

Wound Healing in Mammals and Amphibians: Toward Limb Regeneration in Mammals

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Mammalian fetal skin regenerates perfectly, but adult skin repairs by the formation of scar tissue. The cause of this imperfect repair by adult skin is not
understood. In contrast, wounded adult amphibian (urodeles and anurans) skin is like mammalian fetal skin in that it repairs by regeneration, not scarring. Scar-free wound repair in adult Xenopus is associated with expression of the paired homeobox transcription factor Prx1 by mesenchymal cells of the wound, a feature shared by mesenchymal cells of the regeneration blastema of the axolotl limb. Furthermore, mesenchymal cells of Xenopus skin wounds that harbor the mouse Prx1-limb-enhancer as a transgene exhibit activation of the enhancer despite the fact that they are Xenopus cells, suggesting that the mouse Prx1 enhancer possesses all elements required for its activation in skin wound healing, even though activation of the same enhancer in the mouse is not seen in the wounded skin of an adult mouse.

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Publisher

: .,

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Language

English

ISBN/ISSN

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Classification

NONE

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Edition

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Subject(s)

Mammals
Vivena
Wound Healing
Amphibians

Specific Detail Info

Current Topics in Microbiology and Immunology (2013) 367: 33–49

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