PRODUCT LITERATURE

Sevoflurane: Are There Differences in Products?

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Sevoflurane is currently available in the United States from two manufacturers: Ultane
(Abbott Laboratories, Inc.) and a generic product, Sevoflurane Inhalation Anesthetic (Baxter Healthcare Corp.). These products are rated therapeutically
equivalent by the Food and Drug Administration, but there are some differences. Ultane is made in a single-step synthetic process and generic sevoflurane is manufactured using a three-step process. Ultane contains
300 ppm water and generic sevoflurane contains
130 ppm water. Ultane is supplied in a plastic polyethylene naphthalate polymer bottle, while generic sevoflurane is supplied in
lacquer-lined aluminum bottles. The manufacturing processes and impurities, sevoflurane degradation resulting from Lewis acid reactions, and suitability of nonglass containers for sevoflurane are discussed.

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Detail Information

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: .,

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Language

English

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Classification

NONE

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Subject(s)

Sevodex
Sevoflurane

Specific Detail Info

Anesth Analg 2007;104:1447–51

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