PRODUCT LITERATURE

Vitamin D Supplementation During Pregnancy: Double-Blind, Randomized Clinical Trial of Safety and Effectiveness

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The need, safety, and effectiveness of vitamin D supplementation during pregnancy remain controversial. In this randomized, controlled
trial, women with a singleton pregnancy at 12 to 16 weeks’ gestation received 400, 2000, or 4000 IU of vitamin D3 per day until delivery.
The primary outcome was maternal/neonatal circulating 25-hydroxyvitamin D [25(OH)D] concentration at delivery, with secondary
outcomes of a 25(OH)D concentration of 80 nmol/L or greater achieved and the 25(OH)D concentration required to achieve maximal
1,25-dihydroxyvitamin D3 [1,25(OH)2D3] production. Of the 494 women enrolled, 350 women continued until delivery: Mean 25(OH)D
concentrations by group at delivery and 1 month before delivery were significantly different ( p

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Detail Information

Series Title

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Publisher

: .,

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Vitamin D
Force D
CHOLECALCIFEROL

Specific Detail Info

J Bone Miner Res. 2011;26:2338-2340

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