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Impulse control disorders in Parkinson’s disease: Crossroads between neurology, psychiatry and neuroscience

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Non-motor symptoms contribute significantly to Parkinson’s disease (PD) related disability. Impulse control disorders
(ICDs) have been recently added to the behavioural spectrum of PD-related non-motor symptoms. Such behaviours are
characterized by an inappropriate drive to conduct repetitive behaviours that are usually socially inadequate or result in harmful
consequences. Parkinson disease impulse control disorders (PD-ICDs) have raised significant interest in the scientific and medical
community, not only because of their incapacitating nature, but also because they may represent a valid model of ICDs beyond
PD and a means to study the physiology of drive, impulse control and compulsive actions in the normal brain. In this review, we
discuss some unresolved issues regarding PD-ICDs, including the association with psychiatric co-morbidities such as obsessivecompulsive
disorder and with dopamine related side effects, such as hallucinations and dyskinesias; the relationship with executive
cognitive dysfunction; and the neural underpinnings of ICDs in PD. We also discuss the contribution of neuroscience studies
based on animal-models towards a mechanistic explanation of the development of PD-ICDs, specifically regarding corticostriatal
control of goal directed and habitual actions

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: .,

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Language

English

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NONE

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Subject(s)

Leparson
Dopamine HCL

Specific Detail Info

Behavioural Neurology 27 (2013) 547–557

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