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LITERATURE

The Pathogenesis of Fever-Induced Febrile Seizures and Its Current State


Febrile seizures, commonly in children between the ages of 3 months to 5 years, are a neurological abnormality characterized by
neuronal hyper-excitability, that occur as a result of an increased core body temperature during a fever, which was caused by an underlying
systemic infection. Such infections cause the immune system to elicit an inflammatory response resulting in the release of cytokines from macrophages.
The cytokines such as interleukin (IL)- 1β, IL-6, and tumour necrosis factor-α (TNF-α) combat the infection in the localized area ultimately
spilling over into circulation resulting in elevated cytokine levels


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English
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NONE
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DOI: 10.1177/2633105520956973
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