THERAPEUTIC CLASS

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk

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In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and trabecular bone form a biocomposite referred to as the osteochondral unit that is uniquely adapted to the transfer of load. During the evolution of the osteoarthritic process the compositions, functional properties, and structures of these tissues undergo marked
alterations. Although pathological processes might selectively target a single joint tissue, ultimately all of the components of the osteochondral unit will be affected because of their intimate association, and thus the biological and physical crosstalk among them is of great importance.

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: .,

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English

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NONE

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Central Nervous System

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