PRODUCT LITERATURE

Discovery and Validation of a Molecular Signature for the Noninvasive Diagnosis of Human Renal Allograft Fibrosis

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In the discovery set, urinary cell levels of the following mRNAs were significantly associated with the presence
of allograft fibrosis: vimentin (PG0.0001, logistic regression model), hepatocyte growth factor (PG0.0001), >Ysmooth
muscle actin (PG0.0001), fibronectin 1 (PG0.0001), perforin (P=0.0002), plasminogen activator inhibitor 1
(P=0.0002), transforming growth factor A1 (P=0.0004), tissue inhibitor of metalloproteinase 1 (P=0.0009), granzyme
B (P=0.0009), fibroblast-specific protein 1 (P=0.006), CD103 (P=0.02), and collagen 1A1 (P=0.04). A fourgene
model composed of the levels of mRNA for vimentin, NKCC2, and E-cadherin and of 18S ribosomal RNA
provided the most accurate, parsimonious diagnostic model of allograft fibrosis with a sensitivity of 93.8% and a
specificity of 84.1% (PG0.0001). In the independent validation set, this same model predicted the presence of
allograft fibrosis with a sensitivity of 77.3% and a specificity of 87.5% (PG0.0001).

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Detail Information

Series Title

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Publisher

: .,

Collation

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Language

English

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Classification

NONE

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Edition

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Subject(s)

Cardiovascular & Hematopoietic System

Specific Detail Info

Transplantation 2012;93: 1136Y1146

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