THERAPEUTIC CLASS

The Role of Angiotensin-Converting Enzyme Polymorphism in Congestive Heart Failure

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Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase, with primary known functions of converting angiotensin I into
the vasoactive and aldosterone-stimulating peptide angiotensin II and inactivating bradykinin. There is high variability among
individuals in ACE concentrations, mainly due to the presence of a genetic polymorphism. The ACE gene has, in fact, insertion/
deletion polymorphism in intron 16, consisting of a 287-base pair Alu repeat sequence, with three genotypes: insertion polymorphism, insertion/deletion polymorphism, and deletion polymorphism

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: .,

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Language

English

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Classification

NONE

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Subject(s)

Cardiovascular & Hematopoietic System

Specific Detail Info

CHF. 2004;10:87–95

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