Image of The Role of Angiotensin-Converting Enzyme Polymorphism in Congestive Heart Failure

LITERATURE

The Role of Angiotensin-Converting Enzyme Polymorphism in Congestive Heart Failure


Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase, with primary known functions of converting angiotensin I into
the vasoactive and aldosterone-stimulating peptide angiotensin II and inactivating bradykinin. There is high variability among
individuals in ACE concentrations, mainly due to the presence of a genetic polymorphism. The ACE gene has, in fact, insertion/
deletion polymorphism in intron 16, consisting of a 287-base pair Alu repeat sequence, with three genotypes: insertion polymorphism, insertion/deletion polymorphism, and deletion polymorphism


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English
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NONE
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CHF. 2004;10:87–95
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