THERAPEUTIC CLASS

Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis

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This review considers critically the evidence for the involvement of mediators of innate and acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innate immunity, including phagocytic leukocytes, complement, and
proinflammatory cytokines, contribute to atherogenesis. In addition, adaptive immunity, with its T cells, antibodies, and immunoregulatory cytokines, powerfully modulates disease activity and progression. Atherogenesis involves cross talk between and shared pathways involved in adaptive and innate immunity.

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: .,

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Language

English

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Classification

NONE

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Subject(s)

Allergy & Immune System
Biobran

Specific Detail Info

Circ Res. 2002;91:281-291

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