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Design of Freeze-Drying Processes for Pharmaceuticals: Practical Advice


Design of freeze-drying processes is often approached with a “trial and error” experimental plan or, worse yet, the protocol used in the first laboratory run is adopted without further attempts at optimization. Consequently, commercial freeze-drying processes are often neither robust nor efficient. It is our thesis that design of an “optimized” freeze-drying process is not particularly difficult for most products, as long as some simple rules based on well-accepted scientific principles are followed


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English
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NONE
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Pharmaceutical Research, Vol. 21, No. 2, February 2004
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