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LITERATURE

A Comparison of Oral Procaterol and Albuterol in Reversible Airflow Obstruction


The efficacy and safety of orally administered procaterol hydrochloride, a potent ~2­ adrenergic bronchodilator, was compared with that of albuterol in an eight-center, double-blind study conducted in 223 patients with mild to moderate, reversible bronchial airway obstruction. After a 1-wk placebo washout period, patients were administered either procaterol 0.05 mg twice daily for 2 wk followed by 0.10mg twice daily for 10 wk or albuterol 2 mg three times a day for 2 wk followed by 4 mg three times a day for 10wk. Spirometry determinations 1.5h postdose showed consistently greater percent improvements from predose in FVC, FEV" and FEF25- 75 with procaterol than withp albuterol at Weeks 1,2,4,8, and 12. 1i'eatment differences were statistically significant (a =0.05)
after 2 wk, 2 months, and 3 months of treatment


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Proterol-002Available

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